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Calcutta University - DBT Interdisciplinary Program in Life Sciences
Molecular Mechanism of Plant-microbe interactions
Dept of biochemistry
My laboratory is working with
1. The effects of biotic and abiotic stress in jute with emphasis on Macrophomina infection and drought.
2. The purification and characterization of several microbial enzymes including protease, cellulase, pectate lyase and laccase. These enzymes are also being treated with nano-particles e.g. Ca and Cu to enhance their activity and explore their potential use as industrial catalysts
Dept of Biochemistry
Pathogenic host microbe interaction
With the aim of understanding the plant-pathogen interaction associated with yellow vein mosaic disease of Hibiscus cannabinus, evidence is presented showing that under viral infection, NO and other NO-derived products are overproduced, which leads to tyrosine nitration of proteins indicating that nitrosative stress could participate, as a significant component, in the mechanism of hypersensitive response. In addition, induction of inducible nitric oxide synthase like activity was observed only in viral infected plant. Our focus is on understanding the role of nitric oxide in compatible plant pathogen interaction. We are investigating the complexity of the interplay betweennecrotrophic pathogen Macrophominaphaseolina and the host plant Corchoruscapsularis in charcoal rot disease in terms of nitric oxide production.
Beneficial host microbe interaction
With the aim of understanding the role of nitric oxide in symbiosis, we are using Medicago sativa and Sinorhizobiummeliloti as the model plant and the corresponding partner organism. We are also comparing similar response in Arachis hypogea: Bradyrhizobium system.
Dept of Biochemistry
Photosynthetic light harvest
Evolution of root nodule symbiosis
Department of Microbiology
The research group is involved in molecular modelling and dynamics besides in silico protein-protein interaction study of plant and animal Leucine-rich Repeat (LRR) proteins (PGIP & TLR respectively) involved in innate immunity. The aim is to address issues of hampered crop yield due to fungal infection and therapeutics against human diseases respectively, in addition to building up knowledge of how and why this unique repeat fold has been popularly used.
Identification of flavonoids with antiamyloidogenic properties and or with properties to inhibit beta-secretase using in vitro studies is a parallel research interest of the group. In future the laboratory plans to design lead compounds for therapeutics in not only Alzheimer’s disease but other neurodegenrative diseases as well
Anirban Siddhanta, Ph.D.
Department of Biochemistry, University of Calcutta
Biochemical study on the phosphoinositide signaling pathways to elucidate:
1. Regulation of the subcellular localization of Phosphoinositide kinase in cancer cells
2. Mechanism of apoptotic death of pancreatic beta cells
3. Intracellular trafficking of tyrosinase in melanocytes
4. Legume rhizobia interaction during symbiotic nitrogen fixation
5. Development of new generation antileishmanial nano materials