Areas of research - BIOMEDICAL SCIENCES

reserch_iamge
 
angan_gupta

Anjan Dasgupta

Professor

Dept of Biochemistry
adgcal@gmail.com

1) Nanoscale interaction between nanoparticles (carbon nanotubes in particular)with different bio molecules and organic molecules in solid phase:a new way for characterization and sensing of interacting molecules.
a)Solid phase interaction between carbon nanotubes with bio molecules and organic molecules for proper understanding in molecular mechanism of the nature of short range interaction which is a new potent approach for characterization (or discrimination) of nanoparticles or bio molecules and making bio-sensors as well.
b) Sensing and molecular discrimination between amphiphilic molecules (lipids in particular).
c) A novel carbon nanotube self-assembly based molecular machine for making versatile molecular trap.

2) The differential response of proteins (structural and functional) towards magnetic nanoparticles in absence and presence of static magnetic field and its implications in the instant cell behavior study upon exposure of magnetic field.
a) Label free cell sorting using magnetic perturbation
b) Self assembly studies using megnetic field
c) Magnetic response of cells

3) Chiral Nanoform – and their special status from chemical and drug delivery aspects
a) Synthesizing different chiral nanoparticles
b) Conjugating such chiral forms with drugs
c) Effect of laser on chiral nanomaterial and the consequent cell response.

anindita

Anindita Ukil

Assistant Professor

Department of Biochemistry
aninditau@yahoo.com

Macrophages are primary defense cell line of our body and are centrally located in the host response to infection. Despite this well equipped machinery, some intracellular pathogens target macrophages for infection. Each of them adopts unique strategies to subvert macrophage antimicrobial functions and manipulation of macrophage signaling pathways plays a major role in this regard. We are presently working on visceral leishmaniasis, a macrophage-associated fatal disease, which is caused by the protozoan parasite, Leishmania donovani, which resides and multiplies within the phagolysosomes of the host macrophages. Our aim is to explore the mechanism by which Leishmania neutralize the macrophage microbicidal machinery. One of the mechanisms is to interfere with signal transduction from cell surface to nucleus for manipulation of ultimate downstream effects

anirban

Anirban Siddhanta

Associate Professor

Department of Biochemistry
asiddhanto@yahoo.com

Cell Biology/Biochemistry

Characterization of phospholipids with a special reference to phosphoinositides, i.e. inositol phospholipids that play major role as a constituent of biomembranes and as important signaling molecules

Role of cell signaling in the apoptotic death of pancreatic beta cells during diabetes

Protein structure-function:

Regulation of the activities of phosphoinositide kinases by post-translational covalent modification and by other protein-protein interactions

Phospholipid signaling in:

1) Plant-microbe interaction

dhrubajyoti_chattopadhyay

Dhrubajyoti Chattopadhyay

Guha Professor & Pro-Vice

Chancellor(Academic affairs), University of Calcutta
dhrubajyotic@gmail.com

Development of Potent Anti-viral Agent(s) Against Chandipura Virus

Microbial Bio-diversity in Wet-Land area: A metagenomic approach

Molecular Mechanism of Glutamic Acid induced Cell Migration in Neutrophils

geetanjali_sundaram

Geetanjali Sundaram

Assistant Professor

Dept of Biochemistry
geetanjali.sundaram@gmail.com

The research in the lab deals with the regulation of cell cycle by MAP Kinases in the model eukaryote Schizosaccharomyces pombe. Our long term goals aim at developing a model for all the molecular cross talks involved between the classical cell cycle regulatory pathway and the classical MAPK pathway, their common regulators as well as effectors. Such a model would potentially facilitate the exploitation of MAPKinases like p38 as well as certain cell cycle regulatory molecules such as Cdc25 as therapeutic targets against cancer.

maitree_bhattacharya

Maitree Bhattacharya

Associate Professor

Dept of Biochemistry
mbbioc@caluniv.ac.in

Protein structure and function

Oxidative stress and Diabetes Mellitus

Hemoglobin and Red blood Cell

Chronic Arsenic toxicity, role of nutrition and oxidative stress

Microbial ecology

Leghemoglobin–biochemical and biophysical characterisation

mkprodder

Mrinal K Poddar

Professor

Dept of Biochemistry
poddarmk@yahoo.com

1.Neurobiochemical and pharmacological studies of psychoactive drugs (diazepam/chlorpromazine/THC/Li etc.) at different ambient temperature in relation to their action on different brain region(s) including cerebral cortex, hypothalamus, corpus striatum,hippocampus etc.at the level of neurotransmitters (serotonergic, dopaminergic, cholinergic, GABAergic and glutamietargic.) activiti

2. Neuro-immune regulation in relation to (a) aging and age-induced neurodegeneration and nutritional status of the diet (particularly with varying protein-carbohydrate ratio); (b) Long-term consumption of caffeine in the development of Ehrlich Ascites Tumor; (c) Food additive (synthetic food colour)-induced neurotoxicity and change in behavior.

3. Role of nutritional status with special emphasis on micronutrients in arsenic-induced neurotoxicity at the level of brain regional GABA/Glutamatergic activities.

4. Aroma oil-induced mood elevation in relation to brain regional serotonergic function including receptor activity.

pkbag

Prasanta Kumar Bag

Associate professor

Dept of Biochemistry
pkbbioc@caluniv.ac.in

Pathogenesis of enteric bacteria:Our laboratory is involved on isolation and characterization of enteropathogens from environmental samples, to elucidate the ecology and public health significance of these enteropathogens in the aquatic environment. Monitoring existing environmental strains and undertaking detailed studies of how pathogenic strains evolved from them is essential to our understanding of human disease. Our laboratory demonstrated that Vibrio cholerae non-O1, non-O139 and Aeromonas hydrophila isolated from natural surface water from different sites sampled in diarrhea endemic zones in Kolkata were having pathogenic potential. We have also developed a simple latex agglutination based diagnostic technique for detection of Shiga toxin-producing Escherichia coli. Our present focus is on the mechanism of pathogenesis of some enteric bacteria.

Antimicrobial activity from medicinal plants: Emergence of resistance to multiple drugs is a serious clinical problem in the treatment and containment of the disease. Ethnopharmacology and natural product drug discovery remains a significant hope to solve that problem. Our research interest is on isolation, purification and characterization and mechanism of antimicrobial activity against enteropathogens from medicinal plants. We have demonstrated the antibacterial, antisecretory and antihemorrhagic activities of Azadirachta indica.

Molecular principles of species interaction in the rhizosphere of a leguminous plant: Biochemical and Metagenomic approaches-While unraveling molecular mechanism of rhizobium legume interaction has attracted the most scientific attention little is known about the community character of the microbes in the rhizosphere of legumes. Establishing a link between microbial diversity in the rhizosphere and the role they play in the natural ecosystem is a major challenge. While rRNA profiling gives an idea of the gross biodiversity, monitoring diversity of functional genes gives an idea about the biochemical interdependence of the community. Some of the functional genes, for example lipase, can be both ecologically enlightening as well as commercially useful. Our laboratory is involved on determination of the microbial community composition (culturable and unculturable) within and outside the rhizosphere of an oil seed legume (Arachis hypogea) on the basis of variations in lipase/esterase specific genomic loci with a view to understand effect of plant-microbe interaction in the respective soil ecosystem. Also the application potential of the identified lipase/esterase (s) would be evaluated.

sanghamitra_sengupta

Sanghamitra Sengupta

Assistant Professor

Dept of Biochemistry
sanghamitrasg@yahoo.com

The major research interests of my laboratory are to understand:

1.Role of innate immune response pathways in Plasmodium falciparum mediated malarial pathogenesis.

2.Molecular mechanisms underlying the hyperplastic and malignant development of prostate gland in human.

3.Somatic instability and DNA repair gene in prostate carcinogenesis.

4.Microbial population dynamics in Rhizosphere of leguminous plant and host-microbe crosstalk.

santasree_mazumdar

Santasree Mazumdar

Associate Professor & Head

Dept of Biochemistry
smbioc@caluniv.ac.in

Clinical Biochemistry and molecular medicine. Proposing medicines from herbal sources for phototherapy treated neonatal jaundice patients.

Proposing a new therapeutic drug from black tea for treating ovarian cancer

Studying metabolomics of diabetes proposing a tissue marker for bioimaging.

Clinical trials (Phase III and IV) of drugs manufactured by reputed pharmaceutical companies.

indu_ch

Indu Bhusan Chatterjee

Professor

Department of Biotechnology
ibc123@rediffmail.com

1. Cellular and molecular mechanisms of cigarette smoke-induced emphysema p-Benzosemiquinone a long-lived radical of cigarette smoke, through formation of p-benzoquinone, produces protein modification, apoptosis and emphysematous lung damage in a guinea pig model developed in our laboratory.

2. Role of NADPH-quinone oxidoreductase and vitamin C deficiency on cigarette smoke/p-benzoquinone-inducedmyelodystrophic syndrome.

3. p-benzoquinone-induced alteration of structure and function of human serum albumin.

4. p-benzoquinone-induced histone modification and epigenetic regulation of gene expression

koustubh_panda

Koustubh Panda

Head & Coordinator, Department of Biotechnology & GCGEB

University of Calcutta
pandak66@yahoo.co.uk kpbcg@caluniv.ac.in

Proteomic Identification of Cigarette Smoke-induced Degraded Proteins in Emphysema

Study of the Role of NO and Nitric Oxide Synthases In Inflammatory Lung Damage

Development of a novel drug for therapeutic inhibition of inducible nitric oxide synthase (iNOS) for clinical control of diseases causally related to its over-expression.

Elucidating the molecular mechanism of Arsenicosis and its prevention

gopal_chakraborti

Gopal Chakraborti

Senior Lecturer

Dept of Biotechnology
gcbcg@caluniv.ac.in

Development of anti-tumor agent from natural compounds targeting tubulin-microtubule system, a major cytoskeleton protein.

Expression of tubulin isotypes for understanding mechanism of drug-resistance and development in cancer

Expression of Plasmodium falciparum tubulin in baculovirus-insect cell system for development of anti-malarial drug’

Tubulin-Microtubule is the prime target for various environmental pollutants and toxicants in cell

Sukhendu_Mandal

Sukhendu Mandal

Assistant Professor

Department of Microbiology
sukhendu1@hotmail.com

The major research interests are:

1.Role of alternate sigma factors in Mycobacterial gene expression. Studies on the alternate RNAP holoenzymes and transcription factors involved during stress.
2.Identification and characterization of novel inhibitors of M. tuberculosis and S. aureus RNA Polymerase focusing on traditional ethnic medicinal plant products.
3.Isolation and characterization of novel bacterial species based on their hydrocarbon or rubber degradation properties.
4.Identification of novel Actinomycetes for their unique antimicrobial components.

SOUMALEE_BASU

Soumalee Basu

Assistant Professor

Department of Microbiology
soumalee@gmail.com

The research group is involved in molecular modelling and dynamics besides in silico protein-protein interaction study of plant and animal Leucine-rich Repeat (LRR) proteins (PGIP & TLR respectively) involved in innate immunity. The aim is to address issues of hampered crop yield due to fungal infection and therapeutics against human diseases respectively, in addition to building up knowledge of how and why this unique repeat fold has been popularly used.

Identification of flavonoids with antiamyloidogenic properties and or with properties to inhibit beta-secretase using in vitro studies is a parallel research interest of the group. In future the laboratory plans to design lead compounds for therapeutics in not only Alzheimer’s disease but other neurodegenrative diseases as well

sanjay_ghosh

Sanjay Ghosh

Associate Professor

Dept of Biochemistry
sgbioc@caluniv.ac.in

Molecular Mechanism of Disease

Nitrosative Stress Response

Increasing number of evidences suggest that reactive nitrogen species (RNSs) and nitric oxide (NO) itself affect the redox state of cells like oxidative stress and modify cellular proteins reversibly or irreversibly. Thus a hostile environment is created which is termed as “nitrosative stress”. Yeasts are very good model for studying the effect of nitrosative stress on cell cycle. Currently we are trying to identify the differentially expressed genes in presence or absence of nitrosative stress using microarray technique in Schizosaccharomyces pombe.

Characterizing the role of Nitric Oxide and Reactive Nitrogen Species in cellular autophagy

Autophagy and apoptosis share common stimuli and signaling pathways. Nitric oxide and reactive nitrogen species are found to play a complex inhibitory effect on apoptosis and autophagy. The main objectives of the project are

(1) How ROS/RNS signals regulate autophagy and apoptosis?

(2) Whether specific ROS/RNS elicit specific autophagic responses?

Biomarkers

Protein tyrosine nitration (PTN) is a selective post-translational modification often associated with nitrosative stress. In a proteomics based project we are analyzing nitrosative stress responsive proteins using differential proteomics in Saccharomyses cerevisiae. We are also investigating in vivo protein targets of tyrosine nitration using two-dimensional (2D) gel electrophoresis followed by MS-MS analysis in Saccharomyses cerevisiae.